{"id":5,"date":"2013-11-22T09:41:00","date_gmt":"2013-11-22T01:41:00","guid":{"rendered":"https:\/\/sjjiang.tcu.edu.tw\/?page_id=5"},"modified":"2021-11-23T09:19:11","modified_gmt":"2021-11-23T01:19:11","slug":"%e5%80%8b%e4%ba%ba%e7%b0%a1%e4%bb%8b","status":"publish","type":"page","link":"https:\/\/sjjiang.tcu.edu.tw\/?page_id=5","title":{"rendered":"\u500b\u4eba\u7c21\u4ecb"},"content":{"rendered":"
\n
\n

\u6c5f\u4fe1\u4ef2, Shinn-Jong Jiun, Ph. D.<\/h1>\n
\n

\"\"\u6c5f\u4fe1\u4ef2 \u52a9\u7406\u6559\u6388<\/p>\n

\u8077\u7d1a: \u52a9\u7406\u6559\u6388 Assistant Professor<\/p>\n

\u8fa6\u516c\u5ba4Office\/\u5be6\u9a57\u5ba4Lab : D404\/D412<\/p>\n

\u96fb\u8a71Tel\uff1a03-8565301 \u5206\u6a5fext. 2426\/2427<\/p>\n

E-mail: sjjiang@mail.tcu.edu.tw<\/a><\/p>\n

\u5b78\u6b77\/Education\uff1a<\/p>\n

\u570b\u7acb\u6210\u529f\u5927\u5b78\u57fa\u790e\u91ab\u5b78\u7814\u7a76\u6240\u535a\u58eb<\/p>\n

PhD, Institute of Basic Medical Sciences, Medical College, National Cheng Kung University, Taiwan<\/p>\n

\u570b\u7acb\u6210\u529f\u5927\u5b78\u751f\u7269\u5316\u5b78\u7814\u7a76\u6240\u78a9\u58eb\u76f4\u653b<\/p>\n

Master, Department of Biochemistry, National Cheng Kung University, Medical College, Taiwan<\/p>\n

\u5927\u540c\u5927\u5b78\u751f\u7269\u5de5\u7a0b\u5b78\u7cfb\u5b78\u58eb<\/p>\n

Bachelor, Institute of Bioengineering, Tatung University, Taiwan<\/p>\n

\u7d93\u6b77\/Work experience\uff1a<\/p>\n

\u6148\u6fdf\u5927\u5b78\u91ab\u5b78\u7cfb\u751f\u5316\u5b78\u79d1\u52a9\u7406\u6559\u6388(2009\/08 ~\u8fc4\u4eca)<\/p>\n

Assistant Professor, Department of Biochemistry, School of Medicine, Tzu Chi University (2009\/08 ~)<\/p>\n

\u570b\u7acb\u6210\u529f\u5927\u5b78\u751f\u7269\u5316\u5b78\u66a8\u5206\u5b50\u751f\u7269\u5b78\u7814\u7a76\u6240\u5c08\u6848\u52a9\u7406\u6559\u6388(2009\/02 ~2009\/07)<\/p>\n

Project Assistant Professor, Department of Biochemistry and Molecular Biology, Medical College, National Cheng Kung University (2009\/02 ~2009\/07)<\/p>\n

\u570b\u7acb\u6210\u529f\u5927\u5b78\u5fc3\u8840\u7ba1\u7814\u7a76\u4e2d\u5fc3\u535a\u58eb\u5f8c\u7814\u7a76\u54e1(2008\/08 ~2009\/02)<\/p>\n

Postdoctor, Cardiovascular Research Center, National Cheng Kung University (2008\/08 ~2009\/02)<\/p>\n

\u535a\u58eb\u5f8c\u7814\u7a76\u54e1University of Washington, Department of Pathobiology, USA, Postdoc Fellow (2005\/10 ~2008\/05)<\/p>\n

\u4e2d\u592e\u7814\u7a76\u9662\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\u535a\u58eb\u5f8c\u7814\u7a76\u54e1(2004\/9 ~2005\/09)<\/p>\n

Academia Sinica, Institute of Molecular Biology, Taiwan, Postdoc Fellow (2004\/9 ~2005\/09)<\/p>\n

\u7814\u7a76\u8208\u8da3\/Research interest:<\/p>\n

l\u00a0\u00a0 \u8840\u7ba1\u751f\u7269\u529f\u80fd\u63a2\u8a0e<\/p>\n

l\u00a0\u00a0 Vascular biology and functional study<\/p>\n

\u9032\u884c\u4e2d\u4e4b\u7814\u7a76\/Current research:<\/p>\n

1. \u7814\u7a76CD93\u5728\u8840\u7ba1\u767c\u708e\u7684\u751f\u7269\u529f\u80fd\u63a2\u8a0e\/ biological functions of CD93 on vascular inflammation<\/p>\n

2. \u6297\u8840\u7ba1\u767c\u708e\u85e5\u7269\u4e4b\u7be9\u9078\/ screening the anti-inflammatory drugs<\/p>\n

\u8aaa\u660e:<\/p>\n

\u52d5\u8108\u7ca5\u72c0\u786c\u5316\u662f\u4e00\u7a2e\u75be\u75c5\uff0c\u6d89\u53ca\u7684\u8840\u7ba1\u58c1\u8102\u8cea\u84c4\u7a4d\uff0c\u6162\u6027\u708e\u75c7\uff0c\u7d30\u80de\u6b7b\u4ea1\uff0c\u8840\u6813\u5f62\u6210\u3002CD93\u662f\u4e00\u7a2e\u65b0\u7684\u8abf\u63a7\u7d30\u80de\u541e\u566c\u529f\u80fd\u548c\u7d30\u80de\u7c98\u9644\u767c\u708e\u76f8\u95dc\u7684\u8abf\u7bc0\u5b50\u3002\u7136\u800c\uff0c\u5b83\u7684\u5206\u5b50\u529f\u80fd\u662f\u672a\u77e5\u7684\u3002 CD93\u662f\u4e00\u7a2e\u4f4d\u5728\u7d30\u80de\u8868\u9762\uff0c\u8207\u7d30\u80de\u819c\u806f\u7d50\u7684\u91a3\u86cb\u767d\uff0c\u9019\u4e9b\u7d30\u80de\u53c3\u8207\u5728\u767c\u708e\u53cd\u61c9\u7684\u904e\u7a0b\u4e2d\uff0c\u5305\u62ec\u5167\u76ae\u7d30\u80de\u548c\u9ad3\u7cfb\u7d30\u80de\u3002\u8840\u6db2\u4e2d\u53ef\u5075\u6e2c\u5230\u53ef\u6eb6\u6027\u5f62\u5f0f\u7684CD93\uff0c\u4e26\u4e14\u5728\u767c\u708e\u7684\u904e\u7a0b\u4e2d\u5176\u6fc3\u5ea6\u6703\u9010\u6f38\u5347\u9ad8\u3002\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cCD93\u662f\u4e00\u7a2e\u767c\u708e\u76f8\u95dc\u7684\u56e0\u5b50\uff0c\u53ef\u6d3b\u5316\u55ae\u6838\u7d30\u80de\uff0c\u85c9\u7531\u523a\u6fc0\u7c98\u9644\u5206\u5b50\u7684\u8868\u9054\uff0c\u7d50\u5408\u4e26\u4e14\u7a7f\u904e\u5167\u76ae\u7d30\u80de\u3002\u55ae\u6838\u7d30\u80de\u7c98\u9023\u5728\u8840\u7ba1\u7684\u767c\u708e\u53cd\u61c9\u52a0\u4e0a\u8de8\u5167\u76ae\u7d30\u80de\u7684\u9077\u79fb\uff0c\u662f\u8840\u7ba1\u767c\u708e\u53cd\u61c9\u6700\u521d\u4e14\u5fc5\u8981\u7684\u6b65\u9a5f\uff0c\u4e26\u4e14\u5728\u6574\u500b\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u904e\u7a0b\u4e2d\u4e0d\u65b7\u767c\u751f\u3002\u56e0\u6b64\uff0c\u7834\u89e3CD93\u8abf\u7bc0\u767c\u708e\u53cd\u61c9\u7684\u5206\u5b50\u6a5f\u5236\uff0c\u65bc\u6025\u6027\u548c\u6162\u6027\u7684\u75c5\u7406\u5177\u6709\u5ee3\u6cdb\u7684\u9069\u7528\u6027\u3002\u672c\u5be6\u9a57\u5ba4\u5728\u7814\u7a76CD93\u5728\u8840\u7ba1\u767c\u708e\u7684\u751f\u7269\u529f\u80fd\u63a2\u8a0e\u4ee5\u53ca\u6297\u8840\u7ba1\u767c\u708e\u85e5\u7269\u4e4b\u7be9\u9078\u3002<\/p>\n

Atherosclerosis is a disease of the vessel wall involving lipid accumulation, chronic inflammation, cell death, and thrombosis. CD93 is a novel regulator of inflammation involved in the regulation of phagocytosis and cell adhesion. However, its molecular function is unknown. CD93 exists as a membrane associated glycoprotein on the surface of cells involved in the inflammatory cascade, including endothelial and myeloid cells. A soluble form (sCD93) is detectable in blood and is elevated with inflammation. Our research findings suggest that CD93 is an inflammatory-associated factor and activates the monocytes bind and transmigrate to endothelial cells via adhesion molecules expression. The adhesions of monocytes to endothelial cells coupled with transendothelial migration are initial and essential steps of inflammatory response in vasculature, and occur continuously throughout the entire atherogenic process. Therefore, deciphering the molecular mechanisms that CD93 regulated inflammatory cascade has wide applicability to acute and chronic pathology. Our lab aims at studying the biological functions of CD93 on vascular inflammation and screening the anti-inflammatory drugs.<\/p>\n

\u7814\u7a76\u8457\u4f5c\/Publications:<\/p>\n

1. Jiang SJ, Hsu SY, Deng CR, Huang HC, Liu SL, Shi GY, Wu HL. Dextromethorphan attenuates LPS-induced adhesion molecule expression in human endothelial cells.<\/a> Microcirculation. 2013;20:190-201. (SCI)<\/p>\n

2. Kao YC, Jiang SJ*, Pan WA, Wang KC, Chen PK, Wei HJ, Chen WS, Chang BI, Shi GY, Wu HL. The epidermal growth factor-like domain of CD93 is a potent angiogenic factor.<\/a> PLoS One. 2012;7:e51647. (SCI) (*co-authors)<\/p>\n

3. Liu SL, Li YH, Shi GY, Tang SH, Jiang SJ, Huang CW, Liu PY, Hong JS, Wu HL. Dextromethorphan reduces oxidative stress and inhibits atherosclerosis and neointima formation in mice<\/a>. Cardiovasc Res. 2009;82:161-169. (SCI)<\/p>\n

4. Jiang SJ, Kuo CC, Berry MW, Lee AW, Campbell LA. Identification and characterization of Chlamydia pneumoniae <\/em>specific antigens which activate\uf020 TNF-a production in RAW 264.7 murine macrophages. Infect. Immun. 2008; 76: 1558-1564. (SCI)<\/p>\n

5. Jiang SJ, Campbell LA, Berry MW, Rosenfeld ME, Kuo CC. Retinoic acid prevents Chlamydia pneumoniae induced foam cell development in a mouse model of atherosclerosis. Microbes Infect. 2008;10(12-13):1393-1397. (SCI)<\/p>\n

6. Kuo CC, Lee A, Jiang SJ, Yaraei K, Campbell LA. Inoculation of Chlamydia pneumoniae<\/em> or Chlamydia trachomatis <\/em>with ligand that inhibit attachment to host cells reduces infectivity in the mouse model of lung infection: implication for anti-adhesive therapy. Microbes Infect. 2007;9:1139-1141. (SCI)<\/p>\n

7. Jiang SJ, Lin TM, Shi GY, Eng HL, Chen HY, Wu HL.<\/a> Inhibition of bovine herpesvirus-4 replication in endothelial cells by arsenite. Antiviral Res. 2004;63:167-175. (SCI)<\/p>\n

8. Jiang SJ, Lin TM, Shi GY, Eng HL, Chen HY, Wu HL.<\/a> Inhibition of bovine herpesvirus-4 replication by arsenite through downregulation of the extracellular signal-regulated kinase signaling pathway. J Biomed Sci. 2004;11:500-510. (SCI)<\/p>\n

9. Huang HC, Shi GY, Jiang SJ, Shi CS, Wu CM, Yang HY, Wu HL.<\/a> Thrombomodulin-mediated cell adhesion: involvement of its lectin-like domain. J Biol Chem. 2003;278:46750-46759. (SCI)<\/p>\n

10. Jiang SJ, Lin TM, Wu HL, Han HS, Shi GY. Decrease of fibrinolytic activity in human endothelial cells by arsenite. Thromb Res. 2002;105:55-62. (SCI)<\/p>\n

11. Lin TM, Shi GY, Jiang SJ, Tsai CF, Hwang BJ, Hsieh CT, Wu HL. Persistent infection of bovine herpesvirus type4 in bovine endothelial cell cultures. Vet Microbiol. 1999;70:41-53. (SCI)<\/p>\n<\/div>\n

<\/p>\n<\/div>\n

<\/p>\n<\/div>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6c5f\u4fe1\u4ef2, Shinn-Jong Jiun, Ph. D. \u6c5f\u4fe1\u4ef2 \u52a9\u7406\u6559\u6388 \u8077\u7d1a: \u52a9\u7406\u6559\u6388 Assistan … \u95b1\u8b80\u5168\u6587 \u500b\u4eba\u7c21\u4ecb<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sjjiang.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages\/5","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sjjiang.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sjjiang.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sjjiang.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/sjjiang.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5"}],"version-history":[{"count":3,"href":"https:\/\/sjjiang.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":25,"href":"https:\/\/sjjiang.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/pages\/5\/revisions\/25"}],"wp:attachment":[{"href":"https:\/\/sjjiang.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}